Industry Status

Pharmaceuticals that are sensitive to oxygen usually require the use of nitrogen to replace the air in the void space of the package or container during the filling production process to prevent deterioration due to oxidation of the pharmaceuticals when exposed to oxygen, thus increasing the stability/shelf life of the pharmaceuticals. The effect of nitrogen filling can be affected by many factors, such as the volume of the product container, the volume of the liquid or powder product to be filled, the speed of filling, the flow pressure of sterile nitrogen, the number of volumes of nitrogen to replace the oxygen in the container or in the residual space at the top of the container after filling at the specified flow pressure or flow rate, and so on.

Solution

IPATEC has rich experience in nitrogen gassing protection, not only in the self-developed automatic filling and closing machine for syringes to achieve the function of nitrogen gassing, but also to help customers in a variety of other brands of filling machine for vails and filling machine for syringes on the successful implementation of a number of cases of nitrogen gassing modification.

Filling Machine for Vials: Both nitrogen gassing before filling and after filling devices adopt horizontal structure. The straight-line air outlet holes are evenly distributed, which are mainly used for the straight-line section of the nitrogen gassing device before filling and after filling. The stopper disc position adopts side air outlet in the form of large holes to maximise the coverage and time of nitrogen gassing; 

Filling Machine for Syringes - Nitrogen Gassing During Filling: The nitrogen gassing device adopts a double-layer design (i.e., filling needle + nitrogen gassing needle design) during the filling process. The filling needle holder is specially processed, so that nitrogen can enter the nitrogen gassing needle smoothly to ensure maximum protection by the nitrogen curtain during the filling process; 

Filling Machine for Syringes - Vent Tube Stoppering with Nitrogen Gassing: The nitrogen gassing device adopts a double-layer design (i.e., stopering tube + nitrogen gassing tube design) during the stoppering process. The stoppering tube bracket is specially processed so that the nitrogen can enter the nitrogen gassing tube smoothly to ensure maximum protection by the nitrogen curtain during the filling process;